Abstract Background Lung disease in cystic fibrosis (CF) patients is dominated by chronic inflammation with an early and inappropriate influx of neutrophils causing airway destruction.Congenic C57BL/6 CF mice develop lung inflammatory disease similar to that of patients.In contrast, lungs of congenic BALB/c CF mice remain unaffected.The basis of th
Understanding the emerging potential of synthetic biology for food science: Achievements, applications and safety considerations
The advent of the first synthetic cell has triggered significant interest in synthetic biology research and its potential impact on various fields, including industry, agriculture, health, and the environment.With its unique blend of molecular biology, genetics, engineering, and computational modeling, synthetic biology is becoming a crucial tool i
The Impact of Audit Committee Effectiveness on Audit Quality: Evidence from the Middle East
This study examines the effect of the characteristics of the audit committee, Napkins as a tool of corporate governance, on audit quality (as measured by audit fees and type of audit agent) among insurance companies listed on the Amman Stock Exchange (ASE), Jordan.The empirical study was conducted on data of all 23 listed insurance companies for th
Knowledge, attitudes and perceptions of a patient population on the COVID-19 vaccine rollout
Background: The coronavirus disease 2019 (COVID-19) pandemic has had dire effects on South Africa.Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are critical in the fight against COVID-19.This study is necessary to optimise vaccine acceptance.Aim: To determine the knowledge, attitudes and perceptions of a patient popu
Remodeling of the Microvasculature: May the Blood Flow Be With You
The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands.Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks.This is achieved by remodeling of the capi